It may be diluted in volumes of 50 to 200 ml and infused intravenously over 15 to 30 minutes or administered by iv push over 3 minutes. To complete a visual compatibility study of iv pantoprazole with 17 other iv medications, as well as with a mixture of 3. Patients receiving iv pantoprazole often require concomitant iv drugs and solutions. Guidelines for intravenous albumin administration at stanford health care policy. Two rn signatures are required to verify that physician order is calculated.
Patients were randomized to receive either octreotide 100 mcg subcutaneously every 8 hours stating at least 1 hour prior to. Sandostatin octreotide acetate injection, a cyclic oc tapeptide prepared as a clear sterile solution of octreotide, acetate salt, in a buffere d lactic acid solution for administration by deep subcutaneous intrafat or intravenous iv in jection. Oral octreotide capsules are formulated with a transient permeability enhancer, which enables octreotide to traverse intestinal tight junctions 307. Prediction of the stability of octreotide in a mixed infusion. Octreotide this drug must be guardrailed canterbury district. Hypersensitivity to octreotide or to any component of the formulation. Sandostatin octreotide acetate may be administered subcutaneously or intravenously. Octreotide acetate reference guide for safe and effective use from the.
Octreotide fda prescribing information, side effects and. Assessing the compatibility of packed red blood cells with lactated ringers solution edward j. Ysite injection drug compatibility chart for general wards. Octreotide acetate is stable in sterile isotonic saline solutions or sterile solutions of dextrose 5% in water for 24 hours. Syringe driver drug compatibilities guide to palliative care practice 2016 sodium chloride 0. In a phase 3 study, when 151 patients were switched from. Check tubing below ysite carefully for discoloration, cloudiness or.
Octreotide brand name sandostatin, among others is an octapeptide that mimics natural somatostatin pharmacologically, though it is a more potent inhibitor of growth hormone, glucagon, and insulin than. Sandostatin octreotide acetate has been associated with alterations in nutrient absorption, so it may have an effect on absorption of orally administered drugs. Sandostatin is not compatible in total parenteral nutrition. By continuing to browse this site you are agreeing to our use of cookies. Physical compatibility of pantoprazole with selected. Check tubing below ysite carefully for discoloration, cloudiness or precipitation blank do not mix. Octreotide 100 micrograms1ml solution for injection.
Iv drug compatibility chart the iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Octreotide, a somatostatin analogue, is administered as a bolus dose of 100500. Watson is in medical residency and can answer many drug information questions. Octreotide acetate injection, a cyclic octapeptide prepared as a clear sterile solution of octreotide, acetate salt, in a buffered acetate solution for administration by deep subcutaneous. Each 1 ml vial of dbl octreotide injection contains 0. Prediction of the stability of octreotide in a mixed infusion yuko takasu, miyako yoshida, kaori shimizu, keiichi asahara, mio tange, and takahiro uchida school of pharmaceutical science, mukogawa. Each ml of solution for injection contains 100 micrograms of octreotide as octreotide acetate. Standard dilution amount of drug infusion volume infusion rate. Parenteral nutrition pn and drug compatibility the coinfusion of drugs and pn should be avoided. Octreotide acetate sandostatin, sandostatin lar is an injectable drug prescribed to treat certain people with acromegaly and to treat severe diarrhea and flushing caused by some hormonesecreting. Octreotide acetate is commercially available as an immediaterelease shortacting injection for subq or iv administration and as a longacting extendedrelease suspension for im administration. This iv drug compatibility chart is provided as a quick reference, however since information is subject to change it is advised that you check with a pharmacist for recommendations as well as product information to check for any changes or additional incompatibilities.
Capitals indicate lifethreatening, underlines indicate most frequent. This medication is usually given by injection under the skin, usually 2 to 3 times a day or as directed by your doctor. Syringe driver drug compatibilities guide to palliative. Flush the intravenous line before and after administration of protonix i.
Pn solutions are diverse in their composition and compatibilities with drugs can never be. Reconstituted octreotide lar suspension must never be given iv. Guidelines for use of prostaglandin e1 infusion pge1. Subcutaneous injection is the usual route of administration of sandostatin for control of symptoms. Clinical andor biochemical response may diminish to some extent during prolonged therapy. Sandostatin octreotide acetate studies were not designed to show an effect on the size, rate of growth or development of metastases. In patients with renal impairment the elimination of octreotide from plasm. Megadose intravenous octreotide for the treatment of. Octreotide bcca cancer drug manual page 6 of 9 octreotide developed. Sandostatin octreotide acetate is indicated for the treatment of the profuse watery diarrhea associated with vipsecreting tumors. Pharmacologic management summary nonvariceal bleeding. Have two iv sites to avoid interruption of pge infusion 6. Sandostatin octreotide acetate injection, a cyclic octapeptide prepared.
Iv administration generally is reserved for emergency situations e. The aim of the present study was to assess the physical. Pain with subcutaneous administration may be reduced by using the smallest volume that will deliver the desired dose. The drug is also prescribed for acromegaly a condition in which the body produces too much growth. Octreotide is a drug used to treat diarrhea and skin flushing caused by certain types of cancer. Guidelines for the use of octreotide in the pediatric age group have not been developed, but octreotide is commonly administered as an initial bolus of 1 to 2. Megadose intravenous octreotide for the treatment of carcinoid crisis. For solution and drug compatibility information, see compatibility under stability. Octreotide octreotide acetate injection, solution dailymed.
March 2010 drug std conc std dilution std fluid alt fluid common adult administration rate max admin. Compatibility of intravenous medications with parenteral. Octreotide lar pharmacokinetics is similar once the drug is released from microspheres. Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of drug.
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